Archive for June 29th, 2011

The history of research on serotonin is closely associated with the study of hallucinogenic drugs, which together act as agonists of the serotonin-2A. The basic idea that psychotic states can be seen in psychiatric disorders such as schizophrenia, in part to changes in the serotonergic system began almost simultaneously with the discovery of lysergic acid diethylamide (LSD), psilocybin and serotonin. Sixty years of study, speculation about the beginning of the important relationship between serotonin and psychotic states as drug induced and confirmed on the basis of the disease.

Now modern biochemistry, pharmacology, behavioral science, neuroimaging, genetics and molecular biology are converging to understand how systems interact with other serotonergic and glutamatergic systems modulate monoaminergic states of consciousness and psychotic disorders such as schizophrenia group. This review summarizes the experimental evaluation of the model of serotonin fx compared with the serotonin hypothesis of schizophrenia. Despite the numerous studies linking serotonin and psychosis in the six decades out of exciting new discoveries, the exploration of new mechanisms that could be our understanding of the neurobiology of psychosis induced by drugs and improves disease. Experimental approaches of molecular biology to behavioral studies show that the unifying principle is the effect of 5-HT2A receptor agonists such as mediating the effects of psychedelic hallucinogens and psychotomimetic serotonin too simplistic.